Stephenson Cancer Functional Genomics Core

Overview of Services


About Us:


Gene expression variability across the genome has significant impact on understanding the progress and prognosis of cancer.  The Cancer Functional Genomics Core at the Stephenson Cancer Center offers cutting-edge technology that can provide extremely accurate and reliable expression data to support drug discovery research.  The versatile Agilent SureScan Microarray Scanner system provides the ability to scan genome-wide microarray profiles. For quality assessment of purified RNA and DNA, there are two instruments that include the Biorad Experion™ Automated Electrophoresis Station and Agilent 2100 Bioanalyzer. The Biorad CFX96™ Touch Real-Time PCR Detection System provides highly-reliable quantitative individual gene transcription profiling. Bio-Rad QX100 Droplet Digital PCR is useful to detect the absolute copy number of the genes.  Functional analysis of proteins using biochemical assay can be evaluated with the Perkin Elmer EnVision® Multilabel Reader. An ultimate high-throughput high-content imaging instrument, Operetta from Perkin Elmer can provide high resolution images for screening drugs under live and fixed cell context. Live cell metabolic changes with respect to oxygen consumption and pH change due to respiration can be determined using Xfe 96 extracellular flux analyzer exclusively from Seahorse.




  • Array Scanning and Quantification
  • Reverse Proteomics Array
  • Real-Time PCR
  • Multimodal Assay Screening
  • DNA / RNA / Protein Purity Analysis on a Chip
  • High-content drug screening
  • Metabolic analysis of live cells
  • Absolute allele copy number variation
  • Clonogenic colonies and spheroid counting
  • Chemiluminescent gel imaging
  • Nucleic acid and protein concentrations


  • Agilent SureScan Microarray Scanner System
  • Biorad CFX96™ Touch Real-Time PCR Detection System
  • Perkin Elmer EnVision® Multilabel Reader
  • Biorad Experion™ Automated Electrophoresis Station
  • Agilent 2100 Bioanalyzer
  • Perkin Elmer Janus® Automated Workstation
  • Arrayit Nanoprint™
  • Xfe 96 extracellular flux analyzer
  • Biorad QX100 Droplet Digital PCR
  • Perkin Elmer Operetta®
  • Arrayit Spotware scanner
  • GelCount™ colony counter
  • Genepix microarray scanner
  • Thermo MyECL imager
  • Denovix spectrophotometer




Danny Dhanasekaran, PhD (Interim Director)


Muralidharan Jayaraman, PhD 
Director of Research Core Operations
Phone: 405-271-6890


Getting Started


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Availability Hours

Monday - Friday

8:00 AM - 5:00 PM


Links and Resources


  1. Cancer Functional Genomics Website



Name Role Phone Email Location
Muralidharan Jayaraman, PhD
Director of Research Core Operations
405-271-8001 ex30492
Stanton L. Young Biomedical Research Center (BRC) – Rm. 1401
Sheeja Aravindan
Core Manager

Mingda Yan
Research Associate



Name Description
Microarray scanning service 

The core will provide microarray scanning and to limited extent analysis service. The core has fluorescent high resolution (2 micron) to colorimetric scanners. Microarray slides can be developed by the researcher/user in the core facility and scanned on one of the scanners. Data retrieval can be assisted to limited extent.

Please submit your request on the attached form.

Janus Automated Workstation Assistance 

Automated liquid handling workstation can be utilized for hands-free 96- to 384-wells plates dilutions, plating and assays. Please submit request form for your liquid handling requirements. Once algorithm and protocols are tested and researcher is trained, Janus can be handled by the user, if needed.

Agilent 2100 Bioanalyzer (per run with chip provided by user)   
Biorad CFX96 Touch Real-Time PCR (per run)   
Biorad Experion Automated Electrophresis System (per run with chip provided by user)   
Janus hourly rate   
XF analyzer (Charged per run)   

Service List

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