Stephenson Cancer Tissue Pathology Core

Overview of Services

About Us:

The goal of the Cancer Tissue Pathology Core is to provide high-quality tissue processing, histology and staining services to SCC members and other investigators.  The Core provides tissue processing, embedding, sectioning, histochemical staining of mounted slides, immunohistochemical (IHC) staining for paraffin embedded and frozen tissues, immunocytochemical (ICC) staining for cultured cells (as tissue sections or cytospin slides), evaluation of new antibodies for IHC staining, enzyme histochemistry and special staining.  The Core also provides defined analyses including RNA / DNA preparation, reverse transcription and cDNA synthesis from total RNA, construction, staining and analysis of tissue microarrays, and construction and analysis of reverse proteomics array from user-defined biospecimens.  The Core is flexible to accommodate the development of new techniques and expanding its services based on the research requirements of SCC members and other investigators. 

Core equipment includes a Leica TP1020 Automatic Tissue Processor, Leica EG1150 Embedding station, Leica STS5020 Multistainer, Leica RM2255 Motorized Rotary Microtome,
 a Leica CM1950 Cryostat, a Leica BOND-III automated IHC / ISH-stainer, and a Veridiam Automated Tissue Arrayer along with upright and inverted microscopes, and bright field and fluorescence microscopy.  Aperio whole slide scanning services are available through the Department of Pathology.


Core Services:


  • Histology and Immunohistochemistry
  • Tissue Microarray (TMA)
  • Digitized Slides and Image Analysis
  • Photographic and Imaging Services
  • Molecular Biology Services



Kar-Ming Fung, MD, PhD

Scientific Director


Muralidharan Jayaraman, PhD 
Director of Research Core Operations
Phone: 405-271-6890


Getting Started


  • Sign up for a new account using the link in the upper right hand corner, or click here.

  • Login with your approved credentials in the upper right hand corner.





Availability Hours

Monday - Friday

 8:00 AM - 5:00 PM


Links and Resources


  1. Cancer Tissue Pathology Website


Name Role Phone Email Location
Muralidharan Jayaraman, PhD
Director of Research Core Operations
(405) 271-6890
BRC 1401
Sheeja Aravindan
Lab Manager
(405) 271-6890
BRC 1471
Louisa Williams
(405) 271-6890
BRC 1471


Name Description
RNAscope ISH technology 

Sensitive—detects single RNA molecules

Specific—amplifies signal with simultaneous background noise suppression

Speed—delivers same-day results for manual or automated assays, 2 weeks for new probe design

Context—detects RNA molecules within conserved tissue or cell morphology

Universal—enables detection of virtually any gene, in any tissue from any species

Additional Cryosectioning/block   

First slide and each additional slide is charged separately.

Deparaffinaization of slides   
Double staining   
HE staining   
Immunohistochemistry (per slide)   
Jones Staining service   
Periodic acid-Schiff's base staining   
Processing, Embedding and 1 slide H&E (per block)   
Sectioning for per slide/block   
Trichome staining   

Service List

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Cancer Tissue Pathology Core Charges (11)


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